Business Summary

In this project, we have been integrating cryo-EM, nuclear magnetic resonance, and in-silico computational techniques to develop structural analysis techniques that reveal the three-dimensional structures and dynamic interactions of RNA and RNA complexes, elucidate the structural characteristics of RNA-drug interactions in physiological environments, and develop empirical simulation techniques that can contribute to the discovery and optimization of compounds.

The project also aims to improve the industrial strength of Japanese drug discovery companies by eliminating bottlenecks in RNA-targeted drug discovery through open innovation and by accomplishing the development of both cutting-edge technology and human resources.

Contents

• Research and Development
  • Development of basic technology for functional and structural analysis of RNA and its complexes by cryo-electron microscopy
  • Development of basic technology for functional and structural analysis of RNA and its complexes by nuclear magnetic resonance
  • Development of in-silico structural analysis technology for RNA and its complexes based on experimental results