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| Home > Activities >Research and Development Projects > Structural-guided Drug Development |
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Structural-guided Drug Development |
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Membrane proteins are the targets for nearly 50% of currently used drugs. The importance of information on the conformation and interactions of these proteins for drug discovery has been recognized. During "Structural Proteomics Project", completed in FY 2006, JBIC developed various technologies for analyzing membrane proteins, including ultra-low temperature electron microscopy for highly precise structural analysis, nuclear magnetic resonance (NMR) analysis enabling elucidation of interactions between ligands and proteins, and in silico screening technology. By further developing and refining these analytical methods, basic technologies to support efficient drug discovery would be established and applied to higher levels of drug-discovery processes, etc in the future. |
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- Development of structural analysis technology
Development of analytical tools/techniques for resolving the conformations of real membrane proteins and their complexes on the cell membrane
- Development of interaction analysis technology
Development of analytical tools/techniques for resolving the structure of interactive sites between real membrane proteins and their complexes on the cell membrane and their ligands
- Development of simulation technology
Development of high-precision in silico screening and modeling technologies based on the analytical data obtained through 1 and 2
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